Gene description for ACE2
Gene name	angiotensin converting enzyme 2
Gene symbol	ACE2
Other names/aliases	ACEH
Species	Homo sapiens
Experiment description of studies that identified ACE2 in Embryonic kidney cells
1 Experiment ID 2838 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Western blotting Immuno-EM ELISA PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Embryonic kidney cells Sample name HEK293 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Immuno-EM ELISA Mass spectrometry EV-TRACK -
2 Experiment ID 3418 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Western blotting ELISA PubMed ID 33391636    Organism Homo sapiens Experiment description Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus Authors Cocozza F, Névo N, Piovesana E, Lahaye X, Buchrieser J, Schwartz O, Manel N, Tkach M, Théry C, Martin-Jaular L. Journal name J Extracell Vesicles Publication year 2020 Sample Embryonic kidney cells Sample name 293FT Isolation/purification methods Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting ELISA EV-TRACK -
3 Experiment ID 3419 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Western blotting ELISA PubMed ID 33391636    Organism Homo sapiens Experiment description Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus Authors Cocozza F, Névo N, Piovesana E, Lahaye X, Buchrieser J, Schwartz O, Manel N, Tkach M, Théry C, Martin-Jaular L. Journal name J Extracell Vesicles Publication year 2020 Sample Embryonic kidney cells Sample name 293FT Isolation/purification methods Differential centrifugation Size exclusion chromatography Centrifugal ultrafiltration Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting ELISA EV-TRACK -
4 Experiment ID 2839 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Western blotting PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Embryonic kidney cells Sample name HEK293 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry EV-TRACK -
5 Experiment ID 2842 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Western blotting PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Embryonic kidney cells Sample name HEK293 - Fraction 1 Isolation/purification methods Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -
6 Experiment ID 2843 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Western blotting PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Embryonic kidney cells Sample name HEK293 - Fraction 2 Isolation/purification methods Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -
7 Experiment ID 2844 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Western blotting PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Embryonic kidney cells Sample name HEK293 - Fraction 3 Isolation/purification methods Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -
8 Experiment ID 2845 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Western blotting PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Embryonic kidney cells Sample name HEK293 - Fraction 4 Isolation/purification methods Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -
9 Experiment ID 2846 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Western blotting PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Embryonic kidney cells Sample name HEK293 - Fraction 5 Isolation/purification methods Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -
10 Experiment ID 2847 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Western blotting PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Embryonic kidney cells Sample name HEK293 - Fraction 6 Isolation/purification methods Differential centrifugation Ultracentrifugation OptiPrep density gradient centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -
11 Experiment ID 2839 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Embryonic kidney cells Sample name HEK293 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry EV-TRACK -